Helicobacter pylori overcomes natural immunity in repeated infections
نویسندگان
چکیده
Repeated experimental reinfection of two subjects indicates that Helicobacter pylori infection does not promote an immune response protective against future reinfection. Our results highlight the importance of preventing reinfection after eradication, through public health initiatives, and possibly treatment of family members. They indicate difficulties for vaccine development, especially therapeutic vaccines.
منابع مشابه
Paternal and maternal infection status and Helicobacter pylori in their children.
1. Forthal DN. Cytotoxic T lymphocyte precursors in persons with repeated exposure to human immunodeficiency virus [letter]. J Infect Dis 1999;180: 1406. 2. Goh WC, Markee J, Akridge RE, et al. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of CCR5 coreceptor defects. J Infect Dis 1999;179:548–57. 3...
متن کاملThe Immune Response to Helicobacter pylori
The immune response to Helicobacter pylori involves different mechanisms that are both protective and damaging to the host. The innate and the adaptive immune responses lead to inflammatory as well as anti-inflammatory responses, allowing for persistence of many infections. Thus, developing new therapeutics and effective vaccines against H. pylori has proven to be arduous. Despite many immunisa...
متن کاملUrease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice.
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.
متن کاملDifferential expression of human beta defensin 2 and 3 in gastric mucosa of Helicobacter pylori-infected individuals.
BACKGROUND Antimicrobial peptides are key players of initial innate immune responses to human pathogens. Two major representatives, the human beta defensin 2 and 3 (hBD2 and hBD3), are both known to be regulated by, and to affect viability of, Helicobacter pylori. Previously, it was demonstrated in vitro that H. pylori actively abrogates hBD3 expression during prolonged infections. Here, we com...
متن کاملCell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.
There are two alleles of the vacuolating cytotoxin gene from Helicobacter pylori, which code for toxins with different cell specificities. By analyzing the phenotypes of natural and artificial chimeras between the two forms of the protein, we have delimited a short stretch of amino acids which determine the cell specificity.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2016